Mammalian Base Excision Repair: the Forgotten Archangel
نویسندگان
چکیده
Base excision repair (BER) is a frontline repair system that is responsible for maintaining genome integrity and thus preventing premature aging, cancer and many other human diseases by repairing thousands of DNA lesions and strand breaks continuously caused by endogenous and exogenous mutagens. This fundamental and essential function of BER not only necessitates tight control of the continuous availability of basic components for fast and accurate repair, but also requires temporal and spatial coordination of BER and cell cycle progression to prevent replication of damaged DNA. The major goal of this review is to critically examine controversial and newly emerging questions about mammalian BER pathways, mechanisms regulating BER capacity, BER responses to DNA damage and their links to checkpoint control of DNA replication.
منابع مشابه
Dna Repair
1. DNA Damage 1.1. Spontaneous Alterations of DNA (by Mutator Genes) 1.2. Environmental Damage to DNA 2. DNA Repair by Reversal of Damage Without Excision 2.1. Photoreactivation 2.2. Repair of O-Alkylguanine and Alkylthymine Without DNA trand Excision 3. Base Excision Repair in Non-Mammalian Cells 3.1. DNA Glycosylase in Non-Mammalian Cells 4. Base Excision Repair in Mammalian Cells 4.1. DNA Gl...
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